"The right toe was treated for 20 days with STRIDE™, while the left toe was not. The difference is dramatic. It's incredible to see such visible improvement in such a short period."
Dr. Peter J. Bregman
Podiatrist
How STRIDE™ Works: The Science of Oral and Topical Toenail Fungus Treatment
STRIDE™ has shown a high success rate, with clinical trials reporting an 89% effectiveness in treating toenail fungus. The science behind the solution and, in particular the STRIDE DUO™ therapy not only aims to eradicate the current infection but also helps prevent recurrence by tackling the fungus both locally and systemically.
How STRIDE Approaches Toenail Fungus Treatment
Choosing a toenail fungus treatment is not simply about finding an antifungal medication and applying it to the nail. Established fungal infections can be difficult to treat because the infection may be located beneath and within the nail, while the nail itself creates a physical barrier to medication. Treatment also needs to account for the slow growth of toenails and the possibility of recurrence.
This is why the best toenail fungus treatment can vary from one person to another. A clinician may consider the severity of the infection, how many nails are affected, previous treatment attempts, medical history, and whether oral medication is appropriate before recommending a treatment plan.
Why a Top-Down + Bottom-Up Approach Matters
Topical and oral antifungals reach the infection differently. A topical medication is applied directly to the nail, while an oral antifungal travels through the body and reaches the nail tissue systemically.
STRIDE DUO™ combines these approaches into a top-down + bottom-up protocol. The oral component provides systemic antifungal activity, while STRIDE™ ClearNail Renewal™ is designed to work directly at the nail. The goal is to address the infection through complementary routes rather than relying on only one method.
The topical formula contains urea, lactic acid, terbinafine, and DMSO. Together, these ingredients are designed to support delivery through the nail while providing direct antifungal activity.
Where Oral Terbinafine Treatment Fits
STRIDE™ has shown a high success rate, with clinical trials reporting an 89% effectiveness in treating toenail fungus. The science behind the solution and, in particular the STRIDE DUO™ therapyOral terbinafine treatment is an important prescription option for toenail fungus and is commonly used because systemic medication can reach the nail from within. However, oral antifungals are not appropriate for everyone. A licensed clinician should review a patient's medical history, medications, and other relevant factors before prescribing them. not only aims to eradicate the current infection but also helps prevent recurrence by tackling the fungus both locally and systemically.
STRIDE also uses a Smarter Dosing approach for appropriate candidates, based on pulse dosing rather than continuous daily dosing. The STRIDE protocol uses 7 days of treatment followed by approximately 90 days off, allowing terbinafine to persist in nail keratin between dosing cycles. This protocol should be used only when prescribed and supervised by a qualified clinician.
Treatment Should Be Personalized
There is no universal antifungal nail treatment for everyone. Some patients can be treated with topical remedy only while some may benefit from using an oral therapy or a mixture of both.
The important first step is determining whether the nail changes are actually caused by fungus and understanding the extent of the infection. From there, a clinician can help determine which treatment approach makes the most sense.
Get a treatment that is proven to work!
Two Approaches Rooted in Science and Directed by Your Physician
Depending on your preferences and specific circumstances, your physician will prescribe the best toenail fungus treatment option for you.
STRIDE DUO™
Two-Medication Combo
The treatment combines an oral antifungal, like terbinafine or fluconazole, with STRIDE Clearnail Renewal™ topical solution. Oral medications work from within to disrupt fungal growth, while STRIDE Clearnail Renewal™ targets the infection directly, producing clearer nails in just a few days.
STRIDE SOLO™
topical-Only Approach
For those who prefer not to take oral medication, we offer STRIDE Clearnail Renewal™ topical solution as a standalone treatment. It’s a powerful option that delivers visible results within days, providing an effective and convenient solution for toenail fungus without the need for systemic medications.
Ready To Cure Toenail Fungus For Good?
"I have literally tried everything over the years. Nothing worked until now. STRIDE™ is the real deal."
- Jeff S.
WHAT TO EXPECT DURING TREATMENT?
WEEKS 1-4
STRIDE begins to work internally and externally to fight the infection.
Subtle improvement in appearance
WEEKS 4-8
Visible changes become more noticeable.
- Reduced discoloration
- Smoother nail texture
- Slowed or stopped spreading
WEEKS 12+
New, healthy nail growth begins to emerge.
- Clear nail replaces the damaged one
FULL RECOVERY TIMELINE
Treatment duration typically lasts 3 to 12 months.
- Continued use necessary to maintain clear nails
Toenail Fungus: Understanding Incurable Cases and Treatment Options
Whether you're a patient, healthcare provider, or simply interested in learning more, this video provides valuable insights into navigating the challenges of toenail fungus. Watch now to empower yourself with knowledge and explore the best approaches for achieving healthy nails!
Ready To Cure Toenail Fungus For Good?
"I have literally tried everything over the years. Nothing worked until now. STRIDE is the real deal."
Bethany Mulhanney
STRIDE's Oral Medication Science
The Role of Oral Terbinafine in STRIDE’s Toenail Fungus Treatment
the role of terbinafine in stride's toenail fungus treatment
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The role of Terbinafine
POTENT ANTIFUNGAL ACTION
Terbinafine is an allylamine antifungal that works by specifically targeting the enzyme squalene epoxidase, which is crucial for the biosynthesis of ergosterol, an essential component of fungal cell membranes. By inhibiting this enzyme, Terbinafine causes a deficiency in ergosterol and an accumulation of squalene within the fungal cells, leading to fungal cell death. This mode of action is particularly effective against dermatophytes, the most common fungi responsible for nail infections.
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The role of Terbinafine
HIGH CURE RATES
Clinical studies have consistently shown high cure rates with Terbinafine, often exceeding 70-90% effectiveness, depending on the duration of treatment and severity of the infection. This high efficacy rate is a compelling reason for its primary use in treatment protocols.
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The role of Terbinafine
FAVORABLE PHARMA- COKINETICS
Terbinafine is well-absorbed orally and has excellent tissue penetration, especially into the nails and skin, where it remains for extended periods even after the cessation of treatment. This characteristic ensures ongoing antifungal activity and reduces the total duration of therapy needed to clear the infection.
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The role of Terbinafine
LOW RESISTANCE RATES
Compared to other antifungals, fungi develop resistance to Terbinafine less frequently. This lower resistance rate makes it a reliable choice for treatment, especially in areas where fungal infections are prevalent.
The role of Fluconazole in STRIDE's toenail fungus treatment
Fluconazole serves as an important alternative in the arsenal against toenail fungus, particularly when Terbinafine is not suitable due to medical contraindications or patient preference. Here are several reasons why Fluconazole is chosen as an alternative oral treatment:
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The role of Fluconazole
Broad-Spectrum Antifungal
Fluconazole belongs to the azole class of antifungals, which are known for their broad-spectrum activity. It works by inhibiting the enzyme lanosterol 14α-demethylase, which is involved in the synthesis of ergosterol, a vital component of fungal cell membranes. This disruption leads to increased membrane permeability and eventual fungal cell death. While it is effective against a wide variety of fungi, it is particularly useful against yeast infections and certain molds, which might coexist with or mimic toenail fungus infections.
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The role of Fluconazole
Favorable Dosage Schedule
Fluconazole is often appreciated for its convenient dosing regimen. Unlike some other antifungals that require daily administration, Fluconazole can be prescribed in a once-weekly dosage, which can improve patient compliance and convenience, especially in long-term treatments necessary for clearing nail fungus.
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The role of Fluconazole
Alternative for Sensitive Patients
Patients who experience or are at risk of severe side effects from Terbinafine, such as those with liver issues or who have had adverse reactions to allylamine antifungals, may find Fluconazole a safer alternative. Its different mechanism and metabolic pathway mean it often presents a different side effect profile.
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The role of Fluconazole
Effective Against Resistant Strains
In cases where fungal strains have developed resistance to other treatments, Fluconazole may still prove effective. This makes it a valuable option for treating difficult cases where first-line treatments have failed.
Topical medication science
How STRIDE ClearNail Renewal™ works
Both our primary treatment (oral+topical) as well as our topical-only therapy includes our latest topical formulation which provides a 1-2 punch to toenail fungus when paired with our oral prescriptions. With STRIDE ClearNail Renewal™, patients see visible improvements in as little as a week.
Targeted and Enhanced Penetration
- Direct Application: The topical solution is applied directly to the affected area, allowing for targeted action against the fungus on and under the nail. This local application helps in addressing the fungus right at the source.
- Enhanced Penetration: Ingredients like Ascorbyl glucoside and Lactic acid in the STRIDE ClearNail Renewal™ formulation are not just antifungal; they help loosen the hard structure of the nail, allowing the active antifungal component, Terbinafine, to penetrate more deeply into the nail bed where the fungus thrives.
Accelerates nail recovery
- Multi-Faceted Approach: Using two different treatment modalities can reduce the likelihood of developing resistance to the treatment, as the fungus is being attacked in multiple ways.
- Enhanced Compliance: Knowing that the treatment includes a direct attack on the visible signs of the infection can improve patient motivation and adherence to the treatment regimen. Seeing improvements in the appearance of their nails can encourage patients to continue with the full course of both oral and topical therapies.
Synergistic effect
- Complementary Actions: While the oral medication works systemically to eliminate the fungus from inside the body, the topical solution acts externally. This dual approach attacks the fungus from both sides, increasing the likelihood of a successful treatment outcome.
- Continuous Protection: The topical component can provide ongoing protection against further infection and reinfection during the treatment period, maintaining a fungicidal environment on the nail itself.
Clear Nails, Guaranteed
Compare STRIDE™ to Other Treatments
Not all toenail fungus treatments are created equal. STRIDE™ stands out with its unique dual-action approach that targets the fungus at its source, both externally and internally. Backed by scientific research and clinical success, STRIDE™ outperforms popular over-the-counter products and other prescriptions. Compare the science and results to understand why STRIDE™ is the clear choice for long-term nail health.
Patient Feedback on STRIDE™ Treatments
Real patient testimonials provide insight into the effectiveness of STRIDE™. Learn how our scientifically-backed treatments have helped others overcome toenail fungus. Interested in seeing more?
Conclusion: Understanding STRIDE's treatment options
Toenail fungus is a common yet challenging condition that requires thoughtful consideration of treatment strategies. At STRIDE™, we are committed to providing our patients with effective solutions tailored to their specific needs and health circumstances. For a little more than a $1 a day, STRIDE™ is the most effective toenail fungus prescription treatment available entirely online with no appointment scheduling required. With visible results in just a few days!
Recommended
Oral and Topical Combination
For those who opt for the most robust approach, our STRIDE DUO™ therapy includes an oral medication paired with our STRIDE ClearNail Renewal™ topical solution. This method maximizes the eradication of the fungus by attacking it both systemically and locally, enhancing nail penetration, promoting faster healing, and improving the overall health of the nail.
Alternative
Topical-Only Solution
Our STRIDE SOLO™ therapy focuses on directly combating the fungus at the source with a potent formulation designed to penetrate deeply into the nail bed. Each option is supported by scientific understanding and clinical research, ensuring that you receive a treatment that not only addresses the fungal infection but also suits your personal health profile and preferences.
The science works or get your money back!
Now that you understand the STRIDE™ science, let's take that step towards beautiful feet.
Each option is supported by scientific understanding and clinical research, ensuring that you receive a treatment that not only addresses the fungal infection but also suits your personal health profile and preferences.
"When I started seeing visibly better toenails after about a week, I started to get really excited."
Samantha B.
Anchorage, AK
Frequently Asked Questions
How long does terbinafine take to clear fungus?
Oral terbinafine treatment for toenail fungus typically lasts about 12 weeks. The drug stays in the nail long after the course ends, but visible clearance depends on nail regrowth. Most people see a fully clear nail within 9 to 18 months as healthy nails replace damaged tissue.
Is oral terbinafine effective?
Yes. Oral terbinafine is considered one of the best toenail fungus treatments, with clinical studies reporting cure rates of 70% to 90% depending on severity and treatment length. It works systemically, reaching the nail bed from within, and fungi rarely develops resistance to it.
What's the difference between STRIDE DUO™ and STRIDE SOLO™?
STRIDE DUO™ is a two-part toenail fungus treatment that combines a prescription oral antifungal, such as terbinafine or fluconazole, with STRIDE ClearNail Renewal™ topical to attack fungus from inside and outside. STRIDE SOLO™ uses the topical alone, for those avoiding oral medication. Your physician recommends the best fit.
Is terbinafine the only oral medication used by STRIDE™?
No. Oral terbinafine treatment is STRIDE's primary option, but physicians may prescribe fluconazole when terbinafine isn't suitable, such as for patients with liver concerns, prior reactions, or resistant infections. Fluconazole is often taken once weekly, which many patients find convenient for long-term treatment.
How long does an antifungal nail treatment take to show results?
Most antifungal nail treatments show early changes within 4 to 8 weeks, including reduced discoloration and smoother texture. With STRIDE ClearNail Renewal™, some patients notice visible improvement within a week. Full results take longer, usually 3 to 12 months, because the damaged nail must grow completely.