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The STRIDE Science that Beats Toenail Fungus

STRIDE™ has shown a high success rate, with clinical trials reporting an 89% effectiveness in treating toenail fungus. The science behind the solution and, in particular the STRIDE DUO™ therapy not only aims to eradicate the current infection but also helps prevent recurrence by tackling the fungus both locally and systemically.

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Two Approaches Rooted in Science and Directed by Your Physician

Depending on your preferences and specific circumstances, your physician will prescribe the best toenail fungus treatment option for you.

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Topical + oral

The Power of Two-Medication Combo

The combination includes an oral antifungal, such as terbinafine or fluconazole, STRIDE Clearnail Renewal™ topical solution. This dual approach leverages the strengths of both treatment types to deliver the most effective toenail fungus treatment. Oral medications work systemically to eliminate the fungus from within the body and interferes with fungal cell membrane formation. STRIDE Clearnail Renewal™ provides a direct attack on the fungal cells at the site of the infection and produces clearer looking nails in a matter of days.

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Topical treatment

topical-Only Approach

For those who cannot or do not wish to take oral medication, we offer STRIDE Clearnail Renewal™ topical solution. This is a standalone treatment with benefits of visible results in a matter of days.

Ready To Cure Toenail Fungus For Good?

"I have literally tried everything over the years. Nothing worked until now. STRIDE is the real deal."

- Jeff S.

Verified Buyer

Ready To Cure Toenail Fungus For Good?

"I have literally tried everything over the years. Nothing worked until now. STRIDE is the real deal."
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Bethany Mulhanney

STRIDE's Oral Medication Science

understanding the oral medication in stride's toenail fungus treatment

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the role of terbinafine in stride's toenail fungus treatment

The role of Terbinafine

Potent antifungal action

Terbinafine is an allylamine antifungal that works by specifically targeting the enzyme squalene epoxidase, which is crucial for the biosynthesis of ergosterol, an essential component of fungal cell membranes. By inhibiting this enzyme, Terbinafine causes a deficiency in ergosterol and an accumulation of squalene within the fungal cells, leading to fungal cell death. This mode of action is particularly effective against dermatophytes, the most common fungi responsible for nail infections.

The role of Terbinafine


Clinical studies have consistently shown high cure rates with Terbinafine, often exceeding 70-90% effectiveness, depending on the duration of treatment and severity of the infection. This high efficacy rate is a compelling reason for its primary use in treatment protocols.

The role of Terbinafine


Terbinafine is well-absorbed orally and has excellent tissue penetration, especially into the nails and skin, where it remains for extended periods even after the cessation of treatment. This characteristic ensures ongoing antifungal activity and reduces the total duration of therapy needed to clear the infection.

The role of Terbinafine


Compared to other antifungals, fungi develop resistance to Terbinafine less frequently. This lower resistance rate makes it a reliable choice for treatment, especially in areas where fungal infections are prevalent.

The role of Fluconazole in STRIDE's toenail fungus treatment

Fluconazole serves as an important alternative in the arsenal against toenail fungus, particularly when Terbinafine is not suitable due to medical contraindications or patient preference. Here are several reasons why Fluconazole is chosen as an alternative oral treatment:

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The role of Fluconazole

Broad-Spectrum Antifungal

Fluconazole belongs to the azole class of antifungals, which are known for their broad-spectrum activity. It works by inhibiting the enzyme lanosterol 14α-demethylase, which is involved in the synthesis of ergosterol, a vital component of fungal cell membranes. This disruption leads to increased membrane permeability and eventual fungal cell death. While it is effective against a wide variety of fungi, it is particularly useful against yeast infections and certain molds, which might coexist with or mimic toenail fungus infections.

The role of Fluconazole

Favorable Dosage Schedule

Fluconazole is often appreciated for its convenient dosing regimen. Unlike some other antifungals that require daily administration, Fluconazole can be prescribed in a once-weekly dosage, which can improve patient compliance and convenience, especially in long-term treatments necessary for clearing nail fungus.

The role of Fluconazole

Alternative for Sensitive Patients

Patients who experience or are at risk of severe side effects from Terbinafine, such as those with liver issues or who have had adverse reactions to allylamine antifungals, may find Fluconazole a safer alternative. Its different mechanism and metabolic pathway mean it often presents a different side effect profile.

The role of Fluconazole

Effective Against Resistant Strains

In cases where fungal strains have developed resistance to other treatments, Fluconazole may still prove effective. This makes it a valuable option for treating difficult cases where first-line treatments have failed.

Topical medication science

How STRIDE ClearNail Renewal works

Both our primary treatment (oral+topical) as well as our topical-only therapy includes our latest topical formulation which  provides a 1-2 punch to toenail fungus when paired with our oral prescriptions. With STRIDE ClearNail Renewal™, patients see visible improvements in as little as a week.

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Targeted and Enhanced Penetration

  • Direct Application: The topical solution is applied directly to the affected area, allowing for targeted action against the fungus on and under the nail. This local application helps in addressing the fungus right at the source.
  • Enhanced Penetration: Ingredients like Ascorbic acid (Vitamin C) and Lactic acid in the STRIDE ClearNail Renewal™ formulation are not just antifungal; they help loosen the hard structure of the nail, allowing the active antifungal component, Terbinafine, to penetrate more deeply into the nail bed where the fungus thrives.
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Accelerates nail recovery

  • Multi-Faceted Approach: Using two different treatment modalities can reduce the likelihood of developing resistance to the treatment, as the fungus is being attacked in multiple ways.
  • Enhanced Compliance: Knowing that the treatment includes a direct attack on the visible signs of the infection can improve patient motivation and adherence to the treatment regimen. Seeing improvements in the appearance of their nails can encourage patients to continue with the full course of both oral and topical therapies.
Woman applying medicine to her toenails.Doctor in white gloves examines patient's foot.Beautiful tanned and clean legs on the background of the sea.
Woman applying medicine to her toenails.

Synergistic effect

  • Complementary Actions: While the oral medication works systemically to eliminate the fungus from inside the body, the topical solution acts externally. This dual approach attacks the fungus from both sides, increasing the likelihood of a successful treatment outcome.
  • Continuous Protection: The topical component can provide ongoing protection against further infection and reinfection during the treatment period, maintaining a fungicidal environment on the nail itself.

Conclusion: Understanding STRIDE's treatment options

Toenail fungus is a common yet challenging condition that requires thoughtful consideration of treatment strategies. At STRIDE, we are committed to providing our patients with effective solutions tailored to their specific needs and health circumstances.


Oral and Topical Combination

For those who opt for the most robust approach, our STRIDE DUO™ therapy includes an oral medication paired with our STRIDE ClearNail Renewal™ topical solution. This method maximizes the eradication of the fungus by attacking it both systemically and locally, enhancing nail penetration, promoting faster healing, and improving the overall health of the nail.

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A transparent bottle with a clear toenail fungus treatment liquid with a black cap and the blue STRIDE label on a blue background.

Topical-Only Solution

Our STRIDE SOLO™ therapy focuses on directly combating the fungus at the source with a potent formulation designed to penetrate deeply into the nail bed. Each option is supported by scientific understanding and clinical research, ensuring that you receive a treatment that not only addresses the fungal infection but also suits your personal health profile and preferences.

The science works or get your money back!

Now that you understand the STRIDE science, let's take that step towards beautiful feet.

Each option is supported by scientific understanding and clinical research, ensuring that you receive a treatment that not only addresses the fungal infection but also suits your personal health profile and preferences.

Before-and-after close-up photo of nail fungus treatment.
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"When I started seeing visibly better toenails after about a week, I started to get really excited."
Samantha Bolan with her child playing

Samantha B.

Anchorage, AK